Journal of Applied Hematology

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 12  |  Issue : 1  |  Page : 10--16

Rates of bleeding, thrombosis, and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city, Riyadh, Saudi Arabia


Sultan Alqahtani1, Ahmed Alragea2, Basil Alqahtani2, Nawaf Alhoshan2, Ibrahim Aljasser2, Abdulaziz Alobaied2, Mohammed Alassiri3, Emad Masuadi4, Mohsen Alzahrani5 
1 Department of Basic Medical Sciences, King Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia
2 Department of College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
3 King Abdullah International Medical Research Center; Department of Basic Sciences, College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
4 Department of Medical Education, Research Unit, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
5 King Abdullah International Medical Research Center; Department of Oncology, Division of Stem Cell Transplantation and Cellular Therapy, King Abdulaziz Medical City, Riyadh, Saudi Arabia

Correspondence Address:
Dr. Sultan Alqahtani
Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh
Saudi Arabia

BACKGROUND: Bleeding tendency and thrombosis are two major hematological complications observed in patients after hematopoietic cell transplantation (HCT). Although these complications are well reported in western communities, they are not well established in Saudi Arabia. OBJECTIVES: This retrospective study investigated the rates of bleeding, thrombosis, and survival in Saudi and non-Saudi patients who underwent HCT at King Abdulaziz Medical City, Riyadh, Saudi Arabia, from 2010 to 2017. METHODS AND MATERIALS: A total of 372 Saudi and non-Saudi patients of both sexes with leukemia, anemia disorders, lymphoma, and other types of pathological disorders who underwent autologous or allogeneic HCT were included in this study. Patient data including age, sex, nationality, type of cancer, transplant type, coagulation profile, date of operation and discharge, treatment, and other outpatient notes were collected and analyzed using the Chi-square test. RESULTS: The majority of our patients undergoing allogeneic transplantation had leukemia and other types of anemia disorders including aplastic anemia, sickle cell anemia, and β-thalassemia (79%). However, the majority of patients undergoing autologous transplantation (73.4%) had lymphoma and other types of pathological disorders, including liver cell carcinoma, nephroblastoma, neuroblastoma, myelodysplastic syndromes, and primitive neuroectodermal tumors. Among patients with leukemia, anemia disorders, lymphoma, and other pathological disorders, 2.2%, 1.4%, 1.4%, and 2.8% suffered from thrombosis (overall, 1.9%) and 9.5%, 8.6%, 5.6%, and 11.2% suffered from bleeding, respectively (overall 8.9%). Moreover, the 7-year survival rate among those patients was 82.5%. CONCLUSION: Bleeding occurred at a higher rate after HCT, and the overall 7-year survival rate was relatively high.


How to cite this article:
Alqahtani S, Alragea A, Alqahtani B, Alhoshan N, Aljasser I, Alobaied A, Alassiri M, Masuadi E, Alzahrani M. Rates of bleeding, thrombosis, and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city, Riyadh, Saudi Arabia.J Appl Hematol 2021;12:10-16


How to cite this URL:
Alqahtani S, Alragea A, Alqahtani B, Alhoshan N, Aljasser I, Alobaied A, Alassiri M, Masuadi E, Alzahrani M. Rates of bleeding, thrombosis, and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city, Riyadh, Saudi Arabia. J Appl Hematol [serial online] 2021 [cited 2021 Apr 20 ];12:10-16
Available from: https://www.jahjournal.org/article.asp?issn=1658-5127;year=2021;volume=12;issue=1;spage=10;epage=16;aulast=Alqahtani;type=0