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IMAGE IN HEMATOLOGY
Year : 2021  |  Volume : 12  |  Issue : 1  |  Page : 57

Endothelial cells in the peripheral blood smear: An incidental finding


Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India

Date of Submission04-Aug-2020
Date of Decision17-Aug-2020
Date of Acceptance11-Sep-2020
Date of Web Publication15-Mar-2021

Correspondence Address:
Dr. Aparna Ningombam
Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi - 110 029
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/joah.joah_131_20

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How to cite this article:
Acharya S, Sarkar A, Ningombam A. Endothelial cells in the peripheral blood smear: An incidental finding. J Appl Hematol 2021;12:57

How to cite this URL:
Acharya S, Sarkar A, Ningombam A. Endothelial cells in the peripheral blood smear: An incidental finding. J Appl Hematol [serial online] 2021 [cited 2021 Apr 20];12:57. Available from: https://www.jahjournal.org/text.asp?2021/12/1/57/311331

A 20-year-old male patient attended the emergency department with complaints of shortness of breath. Routine workup with the peripheral blood sample in a K2-ethylenediaminetetraacetate vacutainer was sent for hematological investigations. Complete blood count was unremarkable with hemoglobin of 105 g/L, total leucocyte count of 4.9 × 109/L, and platelet count of 300 × 109/L. Differential count of leukocytes was within normal range. Giemsa-stained peripheral blood smear (PS) showed a small cluster of medium-to-large cells containing oval-grooved nucleus, inconspicuous nucleolus, and a moderate amount of basophilic cytoplasm with fraying. The classical features of grooved nucleus and cytoplasmic fraying confirmed these cells as endothelial cells [Figure 1].
Figure 1: Endothelial cells with grooved nucleus and cytoplasmic fraying (Giemsa, ×1000)

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Endothelial cell clusters in the PS were first reported by Kaznelson et al.[1] They described them in a variety of disorders, mostly infectious and inflammatory. Later, other researchers also documented the presence of these clusters in the PS and hypothesized that vascular injury due to inflammation or preanalytical condition such as venipuncture by thick bore needle may lead to their occurrence.[2]

The morphology of the endothelial cells should not be confused with cells of solid malignancy, and their appearance being the probable consequence of phlebotomy with a barbed needle should be kept in mind.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Acknowledgement

We wish to express our sincere gratitude to our technical staff at the Department of Laboratory Medicine.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Kaznelson P. Seltene Zellformen des strömenden Blutes (Megakaryocyten, Histiocyten, Endothelien). Deutsches Arch. f. klin. Med., 128: 131-150, 1917.  Back to cited text no. 1
    
2.
Cha CH, Kim JU. Endothelial cells in peripheral blood smear: An artifact? Korean J Hematol 2010;45:150.  Back to cited text no. 2
    


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