• Users Online: 606
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2021  |  Volume : 12  |  Issue : 1  |  Page : 10-16

Rates of bleeding, thrombosis, and survival in patients who underwent hematopoietic cell transplantation at king abdulaziz medical city, Riyadh, Saudi Arabia


1 Department of Basic Medical Sciences, King Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia
2 Department of College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
3 King Abdullah International Medical Research Center; Department of Basic Sciences, College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
4 Department of Medical Education, Research Unit, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
5 King Abdullah International Medical Research Center; Department of Oncology, Division of Stem Cell Transplantation and Cellular Therapy, King Abdulaziz Medical City, Riyadh, Saudi Arabia

Correspondence Address:
Dr. Sultan Alqahtani
Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh
Saudi Arabia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/joah.joah_120_20

Rights and Permissions

BACKGROUND: Bleeding tendency and thrombosis are two major hematological complications observed in patients after hematopoietic cell transplantation (HCT). Although these complications are well reported in western communities, they are not well established in Saudi Arabia. OBJECTIVES: This retrospective study investigated the rates of bleeding, thrombosis, and survival in Saudi and non-Saudi patients who underwent HCT at King Abdulaziz Medical City, Riyadh, Saudi Arabia, from 2010 to 2017. METHODS AND MATERIALS: A total of 372 Saudi and non-Saudi patients of both sexes with leukemia, anemia disorders, lymphoma, and other types of pathological disorders who underwent autologous or allogeneic HCT were included in this study. Patient data including age, sex, nationality, type of cancer, transplant type, coagulation profile, date of operation and discharge, treatment, and other outpatient notes were collected and analyzed using the Chi-square test. RESULTS: The majority of our patients undergoing allogeneic transplantation had leukemia and other types of anemia disorders including aplastic anemia, sickle cell anemia, and β-thalassemia (79%). However, the majority of patients undergoing autologous transplantation (73.4%) had lymphoma and other types of pathological disorders, including liver cell carcinoma, nephroblastoma, neuroblastoma, myelodysplastic syndromes, and primitive neuroectodermal tumors. Among patients with leukemia, anemia disorders, lymphoma, and other pathological disorders, 2.2%, 1.4%, 1.4%, and 2.8% suffered from thrombosis (overall, 1.9%) and 9.5%, 8.6%, 5.6%, and 11.2% suffered from bleeding, respectively (overall 8.9%). Moreover, the 7-year survival rate among those patients was 82.5%. CONCLUSION: Bleeding occurred at a higher rate after HCT, and the overall 7-year survival rate was relatively high.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1722    
    Printed22    
    Emailed0    
    PDF Downloaded92    
    Comments [Add]    

Recommend this journal