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| IMAGE IN HEMATOLOGY |
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| Year : 2015 | Volume
: 6
| Issue : 3 | Page : 139 |
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Systemic mastocytosis with associated clonal hematological nonmast cell lineage disease
M Indira1, KK Prabhalakshmi2, Cyril J Kurian1
1 Department of General Medicine, Government Medical College, Thrissur, Kerala, India
2 Department of Pathology, Government Medical College, Thrissur, Kerala, India
| Date of Web Publication | 18-Sep-2015 |
Correspondence Address:
M Indira
Department of General Medicine, Government Medical College, Thrissur
India
 Source of Support: Nil., Conflict of Interest: There are no conflicts of interest.  | Check |
DOI: 10.4103/1658-5127.165647
How to cite this article:
Indira M, Prabhalakshmi K K, Kurian CJ. Systemic mastocytosis with associated clonal hematological nonmast cell lineage disease. J Appl Hematol 2015;6:139 |
How to cite this URL:
Indira M, Prabhalakshmi K K, Kurian CJ. Systemic mastocytosis with associated clonal hematological nonmast cell lineage disease. J Appl Hematol [serial online] 2015 [cited 2023 Sep 27];6:139. Available from: https://www.jahjournal.org/text.asp?2015/6/3/139/165647 |
A 39-year-old male presented with compressive myelopathy due to epidural mass. Work up for multiple myeloma/plasmacytoma was done before decompression surgery. Peripheral smear showed large cells probably the mast cells and no blast cells. Bone marrow aspiration and biopsy showed a collection of atypical mast cells which are CD117 positive [Figure 1] and [Figure 2]. No blast cells were seen in bone marrow study. Later, the excision biopsy of epidural mass showed myeloid sarcoma, possibly myelomonocytic type with mast cell proliferation (myeloperoxidase positive, CD 117 positive in large cells, CD 68 positive, CD 34 negative, CD 56 negative, CD 33 inconclusive) [Figure 3]. Diagnosis of "Systemic mastocytosis with associated clonal hematological non mast cell lineage disease" was made with WHO criteria for the systemic mastocytosis. After decompression surgery, he was started on chemotherapy for acute myeloid leukemia but succumbed to his illness. | Figure 1: Collection of mast cells in bone marrow trephine biopsy H and E ×400
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 | Figure 3: H and E section of space occupying mass (myeloid sarcoma)-×400-myeloid precursors seen
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Acknowledgment
This case was published without images in neurosciences (Neurosciences 2014; Vol 19 (3)) as a clinical note, and clinical profile of the patient is reproduced with permission.
[Figure 1], [Figure 2], [Figure 3]
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