• Users Online: 377
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
IMAGE IN HEMATOLOGY
Year : 2015  |  Volume : 6  |  Issue : 3  |  Page : 139

Systemic mastocytosis with associated clonal hematological nonmast cell lineage disease


1 Department of General Medicine, Government Medical College, Thrissur, Kerala, India
2 Department of Pathology, Government Medical College, Thrissur, Kerala, India

Date of Web Publication18-Sep-2015

Correspondence Address:
M Indira
Department of General Medicine, Government Medical College, Thrissur
India
Login to access the Email id

Source of Support: Nil., Conflict of Interest: There are no conflicts of interest.


DOI: 10.4103/1658-5127.165647

Rights and Permissions

How to cite this article:
Indira M, Prabhalakshmi K K, Kurian CJ. Systemic mastocytosis with associated clonal hematological nonmast cell lineage disease. J Appl Hematol 2015;6:139

How to cite this URL:
Indira M, Prabhalakshmi K K, Kurian CJ. Systemic mastocytosis with associated clonal hematological nonmast cell lineage disease. J Appl Hematol [serial online] 2015 [cited 2021 Dec 2];6:139. Available from: https://www.jahjournal.org/text.asp?2015/6/3/139/165647

A 39-year-old male presented with compressive myelopathy due to epidural mass. Work up for multiple myeloma/plasmacytoma was done before decompression surgery. Peripheral smear showed large cells probably the mast cells and no blast cells. Bone marrow aspiration and biopsy showed a collection of atypical mast cells which are CD117 positive [Figure 1] and [Figure 2]. No blast cells were seen in bone marrow study. Later, the excision biopsy of epidural mass showed myeloid sarcoma, possibly myelomonocytic type with mast cell proliferation (myeloperoxidase positive, CD 117 positive in large cells, CD 68 positive, CD 34 negative, CD 56 negative, CD 33 inconclusive) [Figure 3]. Diagnosis of "Systemic mastocytosis with associated clonal hematological non mast cell lineage disease" was made with WHO criteria for the systemic mastocytosis. After decompression surgery, he was started on chemotherapy for acute myeloid leukemia but succumbed to his illness.
Figure 1: Collection of mast cells in bone marrow trephine biopsy HandE×400

Click here to view
Figure 2: CD117 positivity in bone marrow mast cells×400

Click here to view
Figure 3: Hand E section of space occupying mass(myeloid sarcoma)-×400-myeloid precursors seen

Click here to view


Acknowledgment

This case was published without images in neurosciences (Neurosciences 2014; Vol 19 (3)) as a clinical note, and clinical profile of the patient is reproduced with permission.




    Figures

  [Figure 1], [Figure 2], [Figure 3]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Article Figures

 Article Access Statistics
    Viewed1565    
    Printed44    
    Emailed0    
    PDF Downloaded134    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]