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Year : 2015  |  Volume : 6  |  Issue : 2  |  Page : 88-90

Basics of diagnostic evaluation part 2

Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia

Correspondence Address:
Areej Abdul Ghani Al Fattani
Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, MBC 58, PO Box 3354, Riyadh 11211
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1658-5127.160212

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Despite a long tradition of reporting diagnostic accuracy in terms of sensitivity and specificity, only a minority of physicians correctly interprets and applies this information. Likelihood ratios (LRs) are more intelligible and more meaningful because it connects the preprobability of a person to postprobability that guide the physician to make the right decision about further procedures. Using Fagan Nomogram, makes the application of the LRs more customized to each case. In case of testing a continuous diagnostic test, receiver operating curve is used to set a cut-off value that will be the line between disease and nondisease persons. When determining the cut-off, the trade-offs between increasing the sensitivity with lowering specificity and vise-versa depends on the nature of the disease, as well as whether this test will be used as screening or as diagnostic.

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