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Year : 2015  |  Volume : 6  |  Issue : 2  |  Page : 70-73

Prevalence of human immunodeficiency virus and hepatitis B among multi-transfused thalassemia children

Department of Pediatrics, KT Children Hospital and PDU Government Medical College, Rajkot, Gujarat, India

Correspondence Address:
Jagdish Prasad Goyal
Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1658-5127.160204

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Background: Thalassemia is an inherited disorder of the blood. It is best treated with regular blood transfusion and chelation in developing countries which carries the risk of acquisition of blood-borne viral infection. Though hepatitis B infection can be effectively prevented by vaccine, yet no such vaccine is available for human immunodeficiency virus (HIV). The only strategy to prevent HIV infection is effective screening of blood products. There is a lack of sufficient reported data on transfusion transmitted infections in β-thalassemia major from India. Moreover, data on risk factors associated with HIV transmission in thalassemia children are scanty. Subjects and Methods: This retrospective study was conducted at pediatric thalassemia ward of KT Children Hospital, Rajkot. Case records of patients were retrieved from July 2011 to August 2012. Information regarding age, sex, the number of transfusions, place of transfusion, immunization against hepatitis B, the status of HIV, and hepatitis B surface antigen (HBsAg) were recorded in standard performa. HIV and HBsAg were tested by using patient sera with enzyme-linked immunosorbent assay. Results: Study subject consisted of 237 children. There were 160 males and 77 females. Of 237 children 8 (3.37%) children were found to be HIV positive and 3 (1.26%) children found to be HBsAg positive. Univariate analysis showed that incomplete immunization for hepatitis B was significantly associated with increased risk of HIV (P = 0.00). Conclusion: The prevalence of HIV and hepatitis B is significant in our study. Routine hepatitis B immunization and HIV screening by more stringent method are required.

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