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Year : 2012  |  Volume : 3  |  Issue : 1  |  Page : 45-47

Lymphoma associated with sickle cell disease: a case report

1 Department of Critical Care, College of Medicine King Saud University, Riyadh, Saudi Arabia
2 Department of Surgery, College of Medicine King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
Hadil A Al Otair
Assistant Professor of Medicine, Consultant Department of Critical Care Medicine King Saud University P.O. Box 2925(95) Riyadh 11461
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

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We report a 23-year-old woman with sickle cell disease and rheumatic heart disease. She presented with a pulmonary embolism, despite anticoagulation, and unresolving left lower lobe pneumonia. Chest computed tomography showed hilar and mediastinal lymphadenopathy. Transbronchial fine-needle aspiration was consistent with reactive lymphadenopathy; however, Tru-Cut lung biopsy and transesophageal lymph node biopsy led to a diagnosis of lymphoma. We report this case as a rare association between sickle cell disease and non- Hodgkin lymphoma, possibly leading to a hypercoagulable state and recurrent pulmonary emboli. This case highlights the importance of considering hematological malignancies in the differential diagnosis of lymphadenopathy in sickle cell disease and the necessity of obtaining Tru-Cut biopsies in suspected cases of malignancy.

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