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Year : 2011  |  Volume : 2  |  Issue : 3  |  Page : 257-260

DNA whole genome scanning technology

Hematology Department and Research Centre (Rayne Institute) London, UK and the Regional Laboratories and Blood Bankjeddah, KSA

Correspondence Address:
MD Raiedah Saeed Mohammed Alhameedi
Research Fellow Hematology Department and Research (Rayne Institute) London, UK; Consultant Haematopathologist Head of Hematology and Premarital Testing. Regional Laboratories and Blood Bankjeddah, KSA

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Source of Support: None, Conflict of Interest: None

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Methods of Cytogenetic analysis methods have became part of routine labora­tory testing, providing valuable diagnostic and prognostic information in hema­tologic disorders Karyotypic aberrations contribute to the understanding of the molecular pathogenesis of disease which may lead to improvement in diagnosis, disease stratification, prognostication, therapeutic response, and survival mo­dalities. Most of the progress in this field stems from the application of metaphase cy­togenetics (MC), but novel molecular technologies have been introduced re­cently that complement MC and overcome many of the limitations of traditional cytogenetics, including a need for cell culture. Whole genome scanning using comparative genomic hybridization and single nucleotide polymorphism arrays (CGH-A; SNP-A) can be used for analysis of somatic or clonal unbalanced chro­mosomal defects.

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