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 Table of Contents  
REVIEW
Year : 2011  |  Volume : 2  |  Issue : 3  |  Page : 215-224

Antiplatelet Therapies from Aspirin to Clopidogrel and Beyond: Drug Interactions in the Management of Vascular Disorders


Pharmaceutical Research Institute (PRI), Albany College of Pharmacy, Albany, New York, USA

Date of Web Publication30-Jun-2014

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Source of Support: None, Conflict of Interest: None


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  Abstract 

Antiplatelet drugs represent a key class of drugs that are of proven value in arterial thromboembolic disorders. There is a need for effective, safe antiplatelet agents or their combinations to provide predictable therapeutic benefits, dosage flexibility, and unique pharmacologic profiles, such as rapid onset in acute thrombotic state and sustained antiplatelet effect in chronic platelet activation state (e.g., post-stent placement). Aspirin, clopidogrel or their combination have shown improved clinical outcomes in certain unique settings, and the search for additional antiplatelet agents is ongoing. Current studies suggest that combination antiplatelet therapy with existing agents is best considered a use-adapted strategy, with the greatest clinical benefit of combination therapy realized in acute platelet-activating and pro-thrombotic state.

Keywords: Acute coronary syndrome, clopidogrel, aspirin, myocardial infarction, antiplatelets, combination therapy, ADP receptor antagonist, percutaneous coronary intervention


How to cite this article:
Mousa SA. Antiplatelet Therapies from Aspirin to Clopidogrel and Beyond: Drug Interactions in the Management of Vascular Disorders. J Appl Hematol 2011;2:215-24

How to cite this URL:
Mousa SA. Antiplatelet Therapies from Aspirin to Clopidogrel and Beyond: Drug Interactions in the Management of Vascular Disorders. J Appl Hematol [serial online] 2011 [cited 2021 Dec 2];2:215-24. Available from: https://www.jahjournal.org/text.asp?2011/2/3/215/135590

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