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  Indian J Med Microbiol
 

Figure 1: Erythropoietin receptor and Janus kinases 2–STAT pathway: Activated: EPO signal phosphorylates Janus kinases 2 leading to activation of STAT5 and RAS-MAPK signal transduction pathway which in turn activates several nuclear transcription factors promoting proliferation of erythroid precursors. Inactivated: Recruitment of tyrosine phosphatase (SHP-1) and suppressor of cytokine signaling facilitates dephosphorylation of Janus kinases 2

Figure 1: Erythropoietin receptor and Janus kinases 2–STAT pathway: Activated: EPO signal phosphorylates Janus kinases 2 leading to activation of STAT5 and RAS-MAPK signal transduction pathway which in turn activates several nuclear transcription factors promoting proliferation of erythroid precursors. Inactivated: Recruitment of tyrosine phosphatase (SHP-1) and suppressor of cytokine signaling facilitates dephosphorylation of Janus kinases 2