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CASE REPORT
Year : 2019  |  Volume : 10  |  Issue : 3  |  Page : 99-102

De novo acute myeloid leukemia with t(8;21)(q22;q22) and monosomy 7


1 Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India
2 Department of Hematology, Command Hospital (SC), Pune, Maharashtra, India

Correspondence Address:
Dr. Paresh Singhal
Department of Pathology, Armed Forces Medical College, Pune - 411 040, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/joah.joah_40_19

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The t(8: 21)(q22;q22) is the most common cytogenetic abnormality, usually with a favorable risk, in acute myeloid leukemia (AML). This translocation is not only of diagnostic significance but also has impact on survival outcomes and therapeutic implications. However, patients with adverse outcome in this category of recurrent genetic abnormalities have additional cytogenetic/molecular aberrations with elevated white blood cells count, CD56 expression, and extramedullary manifestations. This case is reported with aim to describe an elderly female who had a sudden downhill clinical course in de novo AML-FAB class M2 in spite of t(8;21), which was associated with monosomy 7 as an additional chromosomal abnormality and absence of high risk clinically relevant genetic mutations.


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