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ORIGINAL ARTICLE
Year : 2016  |  Volume : 7  |  Issue : 3  |  Page : 95-101

Clinical profile of plasma cell leukemia at Tertiary Care Hospital in Kashmir, India


1 Department of Medical Oncology, Sher I Kashmir Institute of Medical Sciences, Soura, India
2 Department of Clinical Hematology, Sher I Kashmir Institute of Medical Sciences, Soura, India
3 Department of Prosthodonsia, Govt. Dental College, Srinagar, Jammu and Kashmir, India

Correspondence Address:
Javvid Muzamil
Department of Medical Oncology, Married Hostel, Room Number F16, Sher I Kashmir Institute of Medical Sciences, Soura, Srinagar - 190 011, Jammu and Kashmir
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1658-5127.192988

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Introduction: Plasma cell dyscrasias represent 1.4–2% of all malignancies and among hematologic malignancies; it constitutes 10% of the tumors. Plasma cell dyscrasias are composed of multiple myeloma (MM), and primary and secondary plasma cell leukemia. Materials and Methods: Primary plasma cell leukemia (pPCL) is a rare and aggressive disease, representing 1–4% of plasma cell dyscrasias. Results: The prognosis of this is very poor with median survival of 8–11 months in different reported series. Discussion: We are reporting a study from our hospital over a period of 8 years and 9 months, in which pPCL was found in 1.8% of MM patients, with slight male predominance and earlier age than MM, and all had high disease burden with high lactate dehydrogenase (LDH), β2-microglobulin, and plasmacytosis. Conclusion: This disease had very aggressive behavior, especially with light chain lambda disease, and all patients succumbed within 8 months of treatment.


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