• Users Online: 428
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
CASE REPORT
Year : 2013  |  Volume : 4  |  Issue : 3  |  Page : 114-117

Bone marrow necrosis in sickle cell disease: A case report and review of the literature


1 Department of Hematology and Blood Bank, Theodor Bilharz Research Institute, Giza, Egypt; Prince Sultan Military Medical City, Central Military Laboratory and Blood Bank, Riyadh, Kingdom of Saudi Arabia
2 Prince Sultan Military Medical City, Central Military Laboratory and Blood Bank, Riyadh, Kingdom of Saudi Arabia
3 Department of Adult Clinical Hematology and Stem Cell Therapy, Riyadh, Kingdom of Saudi Arabia

Correspondence Address:
Ghaleb Elyamany
Theodor Bilharz Research Institute, Egypt, Consultant Hematopathology, PO Box 7897, Riyadh 11159, Kingdom of Saudi Arabia

Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1658-5127.123313

Rights and Permissions

The clinicopathologic entity of bone marrow necrosis (BMN) was first reported by Wade and Stevenson in 1941. BMN is defined as necrosis of the myeloid tissues and stroma without cortical bone involvement. The pathophysiology of BMN remains unclear; however, the occlusion of microcirculation, accompanied by hypoxemia, causes damage to the cells and plays an important role. Severe BMN is rarely diagnosed in living patients. Herein, we report a rare case of severe BMN in a patient with sickle cell disease (SCD) who presented with an unusually severe vaso-occlusive crisis complicated by acute chest syndrome (ACS), pancytopenia, and disseminated intravascular coagulation. Although the clinical features are highly suggestive of BMN, the diagnosis still required a bone marrow (BM) examination because early transfusion therapy can be lifesaving. The prognosis of severe BMN seems to reflect the poor outcomes of such underlying conditions; however, the prognosis of generalized BMN is not so poor when associated with SCD.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3369    
    Printed68    
    Emailed0    
    PDF Downloaded256    
    Comments [Add]    
    Cited by others 1    

Recommend this journal