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ORIGINAL ARTICLE
Year : 2013  |  Volume : 4  |  Issue : 1  |  Page : 19-22

TNF (-308) Polymorphism has no Influence on the Clinical Severity of Sickle Cell Anemia in Saudi Patients


1 Sickle Cell Disease Research Center and Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
2 Blood Transfusion and Hematological Disorders Research Group, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
3 Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
Abdulrahman Alsultan
Department of Pediatrics, College of Medicine King Saud University, P O Box 261691, Riyadh 11342
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


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Tumor necrosis factor (TNF)-(308) promoter polymorphism is associated with the risk of large vessel stroke in African American patients with sickle cell anemia (SCA). The influence of TNF (-308) polymorphism on the clinical severity of SCA in Saudi patients is unknown. Patients homozygous for HbSS (SCA) were enrolled in the study. The frequency of SCA complications was determined for each patient. Laboratory tests included measurement of complete blood count, reticulocytes, lactate dehydrogenase, glucose-6-phosphate dehydrogenase level, and hemoglobin electrophoresis. TNF (-308) promoter polymorphism and presence of a-thalassemia were also determined. A total of 137 patients with SCA were enrolled in our study. Their average age was 18.9 years (range, 1-54 years). G/G in TNF (-308) was observed in 127 patients (92.7%), G/A in 9 patients (6.6%), and A/A in 1 patient (0.7%). Six (4.3%) patients had overt stroke. Of these, 5 patients had the G/G polymorphism and only 1 patient had G/A at TNF (-308) position. This difference was not statistically significant (P = 0.34). TNF promoter polymorphisms did not affect any other clinical or laboratory variables. Our study results suggest that TNF (-308) promoter polymorphism does not influence the severity of the SCA phenotype in Saudi patients. However, a larger sample size is needed to validate our results.


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