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CASE REPORT
Year : 2012  |  Volume : 3  |  Issue : 2  |  Page : 86-88

Acquired Deficiency of Von Willebrand Factor- Cleaving Protease in an HIV-Infected Patient with Relapsing Thrombotic Thrombocytopenic Purpura


1 Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
2 Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
3 Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Correspondence Address:
Abdullah Alqaraawi
Resident, Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


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Thrombotic thrombocytopenic purpura (TTP) can result from a deficiency of von Willebrand factor-cleaving protease (vWF-cp) activity. Patients infected with human immunodeficiency virus (HIV) can present with acquired vWF-cp deficiency. We report a case of an HIV-infected woman who presented with relapsing thrombotic thrombocytopenic purpura (TTP) and was found to have an acquired ADAMTS 13 inhibitor. She was treated with plasma exchange and highly active antiretroviral therapy, which led to fewer clinical relapses.


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