• Users Online: 485
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
ORIGINAL ARTICLE
Year : 2012  |  Volume : 3  |  Issue : 1  |  Page : 39-43

Anemia in Infants with Vitamin D Deficiency Rickets: A Single Center Experience and Literature Review


1 Professor of Pediatrics, Department of Pediatrics, College of Medicine, Taibah University, Saudi Arabia
2 Assistant Professor of Pediatrics, College of Medicine, Taibah University; Consultant hematology/oncology, Medina Maternity & Children's Hospital, Saudi Arabia
3 Consultant hematology/oncology, Medina maternity & Children's Hospital (MMCH), Saudi Arabia

Date of Web Publication30-Jun-2014

Correspondence Address:
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions
  Abstract 

We sought to elucidate the relationship between vitamin D deficiency rickets and anemia. This hospital-based study enrolled infants with rickets who were seen in a 300-bed children's hospital as outpatients or inpatients. Hematological parameters were studied and all cases were categorized as active or healed, based on radiological evidence. For the purpose of this study, iron-deficiency anemia was defined as hemoglobin (Hb) below 11 g/L and mean corpuscular volume (MCV) below 70. In 95 infants, Hb levels ranged from 5 to 14 g/L and 48% of active rickets cases were considered anemic. Hb levels in active rickets indicated anemia and were significantly lower than in healed subjects (10.48 g/L vs. 11.52 g/L, p = 0.037). MCV was low in the active rickets group. Many recent cases of rickets and anemia were reported as myelofibrosis and responded well to vitamin D and calcium. We conclude that 3 types of anemia are associated with vitamin D deficiency rickets. The most common is iron deficiency anemia due to common nutritional and other factors; the second most common is hemolytic anemia, known as Northern syndrome, that has been reported in Native Americans in Canada. The third is a very rare anemia due to myelofibrosis involving platelets and neutrophils.

Keywords: Rickets, vitamin D deficiency, anemia, myelofibrosis, MCV


How to cite this article:
Elidrissy AT, Zolali MA, Hawsawi ZM. Anemia in Infants with Vitamin D Deficiency Rickets: A Single Center Experience and Literature Review. J Appl Hematol 2012;3:39-43

How to cite this URL:
Elidrissy AT, Zolali MA, Hawsawi ZM. Anemia in Infants with Vitamin D Deficiency Rickets: A Single Center Experience and Literature Review. J Appl Hematol [serial online] 2012 [cited 2019 May 26];3:39-43. Available from: http://www.jahjournal.org/text.asp?2012/3/1/39/135681

.




 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract

 Article Access Statistics
    Viewed3209    
    Printed44    
    Emailed0    
    PDF Downloaded228    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]