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ORIGINAL ARTICLE
Year : 2012  |  Volume : 3  |  Issue : 1  |  Page : 21-27

Prognostic Significance of CD202b (Tie-2) Surface Expression in Acute Myeloid Leukemia


Department of Clinical Pathology Department, Ain Shams University, Cairo, Egypt

Correspondence Address:
Hanan M Mahmoud
Ain Shams University Hospitals. Lotfy El-Sayed Street, Abbaseya, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


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CD202b (Tie-2) plays an important role in the regulation of angiogenesis, which is critical in the growth of solid tumors and hematologic malignancies. We investigated Tie-2 surface expression in blasts from 70 Egyptian patients with de novo acute myeloid leukemia (AML). We used flow cytometry to correlate Tie-2 expression with clinical and laboratory parameters and evaluated its prognostic value and impact on treatment response and clinical outcome. The study included 70 patients who were classified according to percent Tie-2 expression: group I patients (32, 45.7%), with ≤20% of cells expressing Tie-2; and group II patients (38, 54.3%), with >20% of blasts expressing Tie-2. No statistically significant difference was found between the patient groups with respect to demographic data; organomegaly; therapy response; and all laboratory data, except for CD13 expression, which was higher in group II patients. High Tie-2 surface expression was associated with a higher mortality rate. Tie-2 expression can be used to predict the survival of AML patients.


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