• Users Online: 532
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
ORIGINAL ARTICLE
Year : 2012  |  Volume : 3  |  Issue : 1  |  Page : 21-27

Prognostic Significance of CD202b (Tie-2) Surface Expression in Acute Myeloid Leukemia


Department of Clinical Pathology Department, Ain Shams University, Cairo, Egypt

Date of Web Publication30-Jun-2014

Correspondence Address:
Hanan M Mahmoud
Ain Shams University Hospitals. Lotfy El-Sayed Street, Abbaseya, Cairo
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions
  Abstract 

CD202b (Tie-2) plays an important role in the regulation of angiogenesis, which is critical in the growth of solid tumors and hematologic malignancies. We investigated Tie-2 surface expression in blasts from 70 Egyptian patients with de novo acute myeloid leukemia (AML). We used flow cytometry to correlate Tie-2 expression with clinical and laboratory parameters and evaluated its prognostic value and impact on treatment response and clinical outcome. The study included 70 patients who were classified according to percent Tie-2 expression: group I patients (32, 45.7%), with ≤20% of cells expressing Tie-2; and group II patients (38, 54.3%), with >20% of blasts expressing Tie-2. No statistically significant difference was found between the patient groups with respect to demographic data; organomegaly; therapy response; and all laboratory data, except for CD13 expression, which was higher in group II patients. High Tie-2 surface expression was associated with a higher mortality rate. Tie-2 expression can be used to predict the survival of AML patients.

Keywords: CD202b, AML, AML prognosis


How to cite this article:
El-Gendi HM, El-Arab SE, Mahmoud HM. Prognostic Significance of CD202b (Tie-2) Surface Expression in Acute Myeloid Leukemia. J Appl Hematol 2012;3:21-7

How to cite this URL:
El-Gendi HM, El-Arab SE, Mahmoud HM. Prognostic Significance of CD202b (Tie-2) Surface Expression in Acute Myeloid Leukemia. J Appl Hematol [serial online] 2012 [cited 2020 Aug 15];3:21-7. Available from: http://www.jahjournal.org/text.asp?2012/3/1/21/135677

.




 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract

 Article Access Statistics
    Viewed1198    
    Printed38    
    Emailed0    
    PDF Downloaded102    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]