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 Table of Contents  
BRIEF COMMUNICATION
Year : 2011  |  Volume : 2  |  Issue : 2  |  Page : 200-202

Impact of Iron Deficiency Anaemia on HbA2 levels


1 Hematology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran
2 Valfajr Medical Centre, Shiraz University of Medical Sciences, Shiraz, Iran

Date of Web Publication30-Jun-2014

Correspondence Address:
Mehran Karimia
MD Haematology Research Centre, Shiraz University of Medical Sciences, Shiraz
Iran
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Source of Support: None, Conflict of Interest: None


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  Abstract 

Iron deficiency anaemia (IDA) is one of the most common causes of anaemia, affecting one-third of the world population. Due to decreased synthesis of haemoglobin, the level of HbA2 in IDA is decreased. The aim of this study was to evaluate which Hb levels decrease in IDA to cause significant laboratory findings of reduced HbA2. The levels of ferritin, HbA2, and haematologic parameters were measured in 202 IDA cases (65 male and 135 female; mean age: 28΁8 years). All subjects were referred to the Valfajr Medical Centre in Shiraz for the premarital screening program. After 2 months iron therapy, the parameters were re-evaluated by the same standard methods. Clinical presentation of IDA including low appetite was present in all cases with Hb <10 g/dL. Numbness of the extremities was present in 88%, pica in 95%, and splenomegaly in 2%. Mean HbA2 level in cases with Hb <10 g/dl was 1.1-1.99% and in those with Hb between 10-13.9 g/dl was 2-3.4%. Before iron therapy, the mean levels of HbA2 were 2.5% and 2.1% in men and women, respectively. After iron therapy, both groups showed increased levels of HbA2 (about 3%). There was a positive correlation between iron therapy and the level of HbA2 (P<.05). There was no correlation between mild IDA and changing HbA2, but the HbA2 level was reduced in moderate to severe IDA.

Keywords: Iron deficiency anaemia, HbA2, iron therapy


How to cite this article:
Yavarian M, Cohan N, Mazarehi H, Roshannia M, Dehbozorgian J, Amirghofran S, Karimia M. Impact of Iron Deficiency Anaemia on HbA2 levels. J Appl Hematol 2011;2:200-2

How to cite this URL:
Yavarian M, Cohan N, Mazarehi H, Roshannia M, Dehbozorgian J, Amirghofran S, Karimia M. Impact of Iron Deficiency Anaemia on HbA2 levels. J Appl Hematol [serial online] 2011 [cited 2020 Apr 1];2:200-2. Available from: http://www.jahjournal.org/text.asp?2011/2/2/200/135695

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