• Users Online: 502
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2010  |  Volume : 1  |  Issue : 4  |  Page : 97-101

Thrombophilia in Saudi Women with Recurrent Fetal Loss


1 Coagulation Laboratory, Department of Physiology, College of Medicine and King Khalid University Hospital, Riyadh, Saudi Arabia
2 Department of Obstetrics of Gynecology, College of Medicine and King Khalid University Hospital, Riyadh, Saudi Arabia
3 Division of Hematology and Oncology, College of Medicine and King Khalid University Hospital,Riyadh, Saudi Arabia

Correspondence Address:
Abdel Galil M Abdel Gader
Department of Physiology, College of Medicine and King Khalid University Hospital, Riyadh 11461
Saudi Arabia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Background/Objective: Recent attention has focused on certain thrombophilic defects that may predispose to pregnancy complications, including recurrent early fetal loss (RFL). This study aims at recording the prevalence of thrombophilia in Saudi women with normal pregnancy and in patients with RFL, in a community where thrombembolic disease is assumed to be rare. In this study, thrombophilic defects are defined by deficiencies in protein S, protein C, and antithrombin (AT), in addition to resistance to activated protein C (APCR). Materai and Methods: A total of 925 patients with RFL [3 or more lost first trimester (12 weeks) pregnancies] were studied 2 months after the loss of their last pregnancy. Women with normal trouble-free pregnancy (n=663) were recruited from the Antenatal Clinic, King Khalid University Hospital, Riyadh, as follows: first trimester (n=132), second trimester (n=293), and third trimester (n=238). Natural coagulation inhibitors and APCR were measured by ELISA-based commercial kits. Results: The prevalence of deficiencies of thrombophilic markers in RFL versus normal pregnancy was as follows: protein S, 7.9% vs. 5.1% (p < 0.036); protein C, 2.4% vs. 0.8 % (P <0.02); AT, 1.6% vs. 0.55% (P <0.053); APCR, 16.9% vs. 5.6% (P <0.036). Conclusion: The result of the present study led us to conclude that in Saudi patients suffering from recurrent pregnancy losses, like many other ethnic groups, thrombophilia, especially APCR, is a major etiological factor, and this makes screening for markers of thrombophilia in RFL all worthwhile.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed941    
    Printed38    
    Emailed0    
    PDF Downloaded89    
    Comments [Add]    

Recommend this journal