• Users Online: 511
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2010  |  Volume : 1  |  Issue : 4  |  Page : 91-96

Flowcytometric Screening for Paroxysmal Nocturnal Hemoglobinuria Abnormal Clones


Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

Correspondence Address:
Salem Khalil
Consultant Hematopathologist Assistant Professor, AlFaisal Universty Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211
Saudi Arabia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

We reviewed all samples submitted for screening of paroxysmal nocturnal hemoglobinuria (PNH) clones during the previous three years at the Flow Cytometry Unit - Hematology Section, Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre (General Organization) that were analyzed for PNH abnormal clones, and reviewed their indications for screening. A total of 184 samples, mainly of peripheral blood from 169 patients (178 peripheral blood and 6 bone marrow samples), were screened with a yield of 10 positive patients(5.9%), the majority of whom were diagnosed as having aplastic anaemia and were referred for bone marrow transplantation. Although PNH is a rare disease, it has always aroused interest in the medical profession. In its early days this was because of its dramatic symptoms. More recently, it is hoped that growing understanding of the molecular defects in PNH and development of new effective therapies will reduce the symptoms and complications of the disease, rendering screening and proper diagnoses by flow cytometry technology a priority.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1070    
    Printed31    
    Emailed0    
    PDF Downloaded96    
    Comments [Add]    

Recommend this journal